Efterpi Nikitopoulou

Affiliations

Medical Research Council Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197 Biomedical Campus, Cambridge, CB2 0XZ, UK.

Publications (13)

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.

Nature communications

Avec: Marco Sciacovelli , Aurelien Dugourd , Lorea Valcarcel Jimenez , Ming Yang , Efterpi Nikitopoulou , Ana S H Costa , Laura Tronci , Veronica Caraffini , Paulo Rodrigues , Christina Schmidt , Dylan Gerard Ryan , Timothy Young , Vincent R Zecchini , Sabrina H Rossi , Charlie Massie , Caroline Lohoff , Maria Masid , Vassily Hatzimanikatis , Christoph Kuppe , Alex Von Kriegsheim , Rafael Kramann , Vincent Gnanapragasam , Anne Y Warren , Grant D Stewart , Ayelet Erez , Sakari Vanharanta , Julio Saez-Rodriguez , Christian Frezza

Cost Effectiveness of Tofacitinib for the Treatment of Active Ankylosing Spondylitis in Greece.

Clinical drug investigation

Avec: George Gourzoulidis , Argyro Solakidi , Marina Psarra , Eleni Nikitopoulou , Charalampos Tzanetakos

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.

Nature

Avec: Alexander Hooftman , Christian G Peace , Dylan G Ryan , Emily A Day , Ming Yang , Anne F McGettrick , Maureen Yin , Erica N Montano , Lihong Huo , Juliana E Toller-Kawahisa , Vincent Zecchini , Tristram A J Ryan , Alfonso Bolado-Carrancio , Alva M Casey , Hiran A Prag , Ana S H Costa , Gabriela De Los Santos , Mariko Ishimori , Daniel J Wallace , Swamy Venuturupalli , Efterpi Nikitopoulou , Norma Frizzell , Cecilia Johansson , Alexander Von Kriegsheim , Michael P Murphy , Caroline Jefferies , Christian Frezza , Luke A J O'Neill

Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo.

Cell reports

Avec: Marie Pereira , Tai-Di Chen , Norzawani Buang , Antoni Olona , Jeong-Hun Ko , Maria Prendecki , Ana S H Costa , Efterpi Nikitopoulou , Laura Tronci , Charles D Pusey , H Terence Cook , Stephen P McAdoo , Christian Frezza , Jacques Behmoaras

Convergent somatic mutations in metabolism genes in chronic liver disease.

Nature

Avec: Stanley W K Ng , Foad J Rouhani , Simon F Brunner , Natalia Brzozowska , Sarah J Aitken , Ming Yang , Federico Abascal , Luiza Moore , Efterpi Nikitopoulou , Lia Chappell , Daniel Leongamornlert , Aleksandra Ivovic , Philip Robinson , Timothy Butler , Mathijs A Sanders , Nicholas Williams , Tim H H Coorens , Jon Teague , Keiran Raine , Adam P Butler , Yvette Hooks , Beverley Wilson , Natalie Birtchnell , Huw Naylor , Susan E Davies , Michael R Stratton , Iñigo Martincorena , Raheleh Rahbari , Christian Frezza , Matthew Hoare , Peter J Campbell

Mechanism of succinate efflux upon reperfusion of the ischaemic heart.

Cardiovascular research

Avec: Hiran A Prag , Anja V Gruszczyk , Margaret M Huang , Timothy E Beach , Timothy Young , Laura Tronci , Efterpi Nikitopoulou , John F Mulvey , Raimondo Ascione , Anna Hadjihambi , Michael J Shattock , Luc Pellerin , Kourosh Saeb-Parsy , Christian Frezza , Andrew M James , Thomas Krieg , Michael P Murphy , Dunja Aksentijević

Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes.

Nature

Avec: Chrysanthi Moschandrea , Vangelis Kondylis , Ioannis Evangelakos , Marija Herholz , Farina Schneider , Christina Schmidt , Ming Yang , Sandra Ehret , Markus Heine , Michelle Y Jaeckstein , Karolina Szczepanowska , Robin Schwarzer , Linda Baumann , Theresa Bock , Efterpi Nikitopoulou , Susanne Brodesser , Marcus Krüger , Christian Frezza , Joerg Heeren , Aleksandra Trifunovic , Manolis Pasparakis

Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation.

FEBS letters

Avec: Fay M Allen , Ana S H Costa , Anja V Gruszczyk , Georgina R Bates , Hiran A Prag , Efterpi Nikitopoulou , Carlo Viscomi , Christian Frezza , Andrew M James , Michael P Murphy

Fumarate induces vesicular release of mtDNA to drive innate immunity.

Nature

Avec: Vincent Zecchini , Vincent Paupe , Irene Herranz-Montoya , Joëlle Janssen , Inge M N Wortel , Jordan L Morris , Ashley Ferguson , Suvagata Roy Chowdury , Marc Segarra-Mondejar , Ana S H Costa , Gonçalo C Pereira , Laura Tronci , Timothy Young , Efterpi Nikitopoulou , Ming Yang , Dóra Bihary , Federico Caicci , Shun Nagashima , Alyson Speed , Kalliopi Bokea , Zara Baig , Shamith Samarajiwa , Maxine Tran , Thomas Mitchell , Mark Johnson , Julien Prudent , Christian Frezza

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.

Nature metabolism

Avec: Jack L Martin , Ana S H Costa , Anja V Gruszczyk , Timothy E Beach , Fay M Allen , Hiran A Prag , Elizabeth C Hinchy , Krishnaa Mahbubani , Mazin Hamed , Laura Tronci , Efterpi Nikitopoulou , Andrew M James , Thomas Krieg , Alan J Robinson , Margaret M Huang , Stuart T Caldwell , Angela Logan , Laura Pala , Richard C Hartley , Christian Frezza , Kourosh Saeb-Parsy , Michael P Murphy

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism.

eLife

Avec: Dylan Gerard Ryan , Ming Yang , Hiran A Prag , Giovanny Rodriguez Blanco , Efterpi Nikitopoulou , Marc Segarra-Mondejar , Christopher A Powell , Tim Young , Nils Burger , Jan Lj Miljkovic , Michal Minczuk , Michael P Murphy , Alex von Kriegsheim , Christian Frezza

Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells.

Cancers

Avec: Ana Carolina B Sant'Anna-Silva , Juan A Perez-Valencia , Marco Sciacovelli , Claude Lalou , Saharnaz Sarlak , Laura Tronci , Efterpi Nikitopoulou , Andras T Meszaros , Christian Frezza , Rodrigue Rossignol , Erich Gnaiger , Helmut Klocker

Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy.

Cell metabolism

Avec: Dorian Forte , María García-Fernández , Abel Sánchez-Aguilera , Vaia Stavropoulou , Claire Fielding , Daniel Martín-Pérez , Juan Antonio López , Ana S H Costa , Laura Tronci , Efterpi Nikitopoulou , Michael Barber , Paolo Gallipoli , Ludovica Marando , Carlos López Fernández de Castillejo , Alexandar Tzankov , Sabine Dietmann , Michele Cavo , Lucia Catani , Antonio Curti , Jesús Vázquez , Christian Frezza , Brian J Huntly , Juerg Schwaller , Simón Méndez-Ferrer

Réseau de co-auteurs

Christian Frezza 12 collaborations

Ana S H Costa 7 collaborations

Laura Tronci 7 collaborations

Ming Yang 6 collaborations

Hiran A Prag 5 collaborations

Michael P Murphy 5 collaborations

Timothy Young 3 collaborations

Anja V Gruszczyk 3 collaborations

Andrew M James 3 collaborations

Marco Sciacovelli 2 collaborations

Christina Schmidt 2 collaborations

Dylan Gerard Ryan 2 collaborations

Vincent Zecchini 2 collaborations

Margaret M Huang 2 collaborations

Timothy E Beach 2 collaborations

Kourosh Saeb-Parsy 2 collaborations

Thomas Krieg 2 collaborations

Fay M Allen 2 collaborations

Marc Segarra-Mondejar 2 collaborations

Aurelien Dugourd 1 collaboration

Lorea Valcarcel Jimenez 1 collaboration

Veronica Caraffini 1 collaboration

Paulo Rodrigues 1 collaboration

Vincent R Zecchini 1 collaboration

Sabrina H Rossi 1 collaboration

Charlie Massie 1 collaboration

Caroline Lohoff 1 collaboration

Maria Masid 1 collaboration

Vassily Hatzimanikatis 1 collaboration

Christoph Kuppe 1 collaboration

Alex Von Kriegsheim 1 collaboration

Rafael Kramann 1 collaboration

Vincent Gnanapragasam 1 collaboration

Anne Y Warren 1 collaboration

Grant D Stewart 1 collaboration

Ayelet Erez 1 collaboration

Sakari Vanharanta 1 collaboration

Julio Saez-Rodriguez 1 collaboration

George Gourzoulidis 1 collaboration

Argyro Solakidi 1 collaboration

Marina Psarra 1 collaboration

Eleni Nikitopoulou 1 collaboration

Charalampos Tzanetakos 1 collaboration

Alexander Hooftman 1 collaboration

Christian G Peace 1 collaboration

Dylan G Ryan 1 collaboration

Emily A Day 1 collaboration

Anne F McGettrick 1 collaboration

Maureen Yin 1 collaboration

Erica N Montano 1 collaboration

Lihong Huo 1 collaboration

Juliana E Toller-Kawahisa 1 collaboration

Tristram A J Ryan 1 collaboration

Alfonso Bolado-Carrancio 1 collaboration

Alva M Casey 1 collaboration

Gabriela De Los Santos 1 collaboration

Mariko Ishimori 1 collaboration

Daniel J Wallace 1 collaboration

Swamy Venuturupalli 1 collaboration

Norma Frizzell 1 collaboration

Cecilia Johansson 1 collaboration

Alexander Von Kriegsheim 1 collaboration

Caroline Jefferies 1 collaboration

Luke A J O'Neill 1 collaboration

Marie Pereira 1 collaboration

Tai-Di Chen 1 collaboration

Norzawani Buang 1 collaboration

Antoni Olona 1 collaboration

Jeong-Hun Ko 1 collaboration

Maria Prendecki 1 collaboration

Charles D Pusey 1 collaboration

H Terence Cook 1 collaboration

Stephen P McAdoo 1 collaboration

Jacques Behmoaras 1 collaboration

Stanley W K Ng 1 collaboration

Foad J Rouhani 1 collaboration

Simon F Brunner 1 collaboration

Natalia Brzozowska 1 collaboration

Sarah J Aitken 1 collaboration

Federico Abascal 1 collaboration

Luiza Moore 1 collaboration

Lia Chappell 1 collaboration

Daniel Leongamornlert 1 collaboration

Aleksandra Ivovic 1 collaboration

Philip Robinson 1 collaboration

Timothy Butler 1 collaboration

Mathijs A Sanders 1 collaboration

Nicholas Williams 1 collaboration

Tim H H Coorens 1 collaboration

Jon Teague 1 collaboration

Keiran Raine 1 collaboration

Adam P Butler 1 collaboration

Yvette Hooks 1 collaboration

Beverley Wilson 1 collaboration

Natalie Birtchnell 1 collaboration

Huw Naylor 1 collaboration

Susan E Davies 1 collaboration

Michael R Stratton 1 collaboration

Iñigo Martincorena 1 collaboration

Raheleh Rahbari 1 collaboration

Matthew Hoare 1 collaboration

Peter J Campbell 1 collaboration

John F Mulvey 1 collaboration

Raimondo Ascione 1 collaboration

Anna Hadjihambi 1 collaboration

Michael J Shattock 1 collaboration

Luc Pellerin 1 collaboration

Dunja Aksentijević 1 collaboration

Chrysanthi Moschandrea 1 collaboration

Vangelis Kondylis 1 collaboration

Ioannis Evangelakos 1 collaboration

Marija Herholz 1 collaboration

Farina Schneider 1 collaboration

Sandra Ehret 1 collaboration

Markus Heine 1 collaboration

Michelle Y Jaeckstein 1 collaboration

Karolina Szczepanowska 1 collaboration

Robin Schwarzer 1 collaboration

Linda Baumann 1 collaboration

Theresa Bock 1 collaboration

Susanne Brodesser 1 collaboration

Marcus Krüger 1 collaboration

Joerg Heeren 1 collaboration

Aleksandra Trifunovic 1 collaboration

Manolis Pasparakis 1 collaboration

Georgina R Bates 1 collaboration

Carlo Viscomi 1 collaboration

Vincent Paupe 1 collaboration

Irene Herranz-Montoya 1 collaboration

Joëlle Janssen 1 collaboration

Inge M N Wortel 1 collaboration

Jordan L Morris 1 collaboration

Ashley Ferguson 1 collaboration

Suvagata Roy Chowdury 1 collaboration

Gonçalo C Pereira 1 collaboration

Dóra Bihary 1 collaboration

Federico Caicci 1 collaboration

Shun Nagashima 1 collaboration

Alyson Speed 1 collaboration

Kalliopi Bokea 1 collaboration

Zara Baig 1 collaboration

Shamith Samarajiwa 1 collaboration

Maxine Tran 1 collaboration

Thomas Mitchell 1 collaboration

Mark Johnson 1 collaboration

Julien Prudent 1 collaboration

Jack L Martin 1 collaboration

Elizabeth C Hinchy 1 collaboration

Krishnaa Mahbubani 1 collaboration

Mazin Hamed 1 collaboration

Alan J Robinson 1 collaboration

Stuart T Caldwell 1 collaboration

Angela Logan 1 collaboration

Laura Pala 1 collaboration

Richard C Hartley 1 collaboration

Giovanny Rodriguez Blanco 1 collaboration

Christopher A Powell 1 collaboration

Tim Young 1 collaboration

Nils Burger 1 collaboration

Jan Lj Miljkovic 1 collaboration

Michal Minczuk 1 collaboration

Alex von Kriegsheim 1 collaboration

Ana Carolina B Sant'Anna-Silva 1 collaboration

Juan A Perez-Valencia 1 collaboration

Claude Lalou 1 collaboration

Saharnaz Sarlak 1 collaboration

Andras T Meszaros 1 collaboration

Rodrigue Rossignol 1 collaboration

Erich Gnaiger 1 collaboration

Helmut Klocker 1 collaboration

Dorian Forte 1 collaboration

María García-Fernández 1 collaboration

Abel Sánchez-Aguilera 1 collaboration

Vaia Stavropoulou 1 collaboration

Claire Fielding 1 collaboration

Daniel Martín-Pérez 1 collaboration

Juan Antonio López 1 collaboration

Michael Barber 1 collaboration

Paolo Gallipoli 1 collaboration

Ludovica Marando 1 collaboration

Carlos López Fernández de Castillejo 1 collaboration

Alexandar Tzankov 1 collaboration

Sabine Dietmann 1 collaboration

Michele Cavo 1 collaboration

Lucia Catani 1 collaboration

Antonio Curti 1 collaboration

Jesús Vázquez 1 collaboration

Brian J Huntly 1 collaboration

Juerg Schwaller 1 collaboration

Simón Méndez-Ferrer 1 collaboration